Sialic acids sweeten a tumor's life

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August undefined, 2024

WebFeb 7, 2024 · Sialic acids. Sialic acids (Sia) comprise a family of about 50 natural derivatives of the nine-carbon sugar neuraminic acid [Citation 6].The unsubstituted form of neuraminic acid contains five hydroxyl, one amine and one carboxyl group ().It is not found in nature, but its N- or О-substituted representatives (sialic acids) are widely distributed in animals and …

Sialic acids in pancreatic cancer cells drive tumour ... - Nature

WebReview Sialic Acids Sweeten a Tumor's Life Christian B€ull, Marieke A. Stoel, Martijn H. den Brok, and Gosse J. Adema Abstract Over four decades ago, speciﬁc tumor … WebMar 3, 2016 · Because the immune-inhibitory effects induced by sialylated pathogens and tumors may be attributed to different configurations of sialic acid-containing glycoproteins or glycolipids, we set out to characterize the effects of sialic acids on DCs and T-cell responses using a well-characterized neoglycoconjugate approach based on the model … simple chat via bluetooth android

Sialic acids sweeten a tumor

WebThe total sialic acid in serum or glycolipid-bound sialic acids is significantly elevated in multiple cancers such as ovarian cancer, leukemia, colorectal cancer, and breast cancer … WebSialic acids represent a family of sugar molecules derived from neuraminic acid that frequently terminate glycan chains and contribute to many biological processes. Already … WebHigh sialic acid content of the cancer glycocalyx has been implicated in both decreased anti-tumor activity and poorer survival outcomes (Brossart et al., 2001). Perhaps most critically, the increased sialic acid content in tumor cells increases the amount of ligands for self-inhibitory siglecs on the immune cell surface (Crocker et al., 2007). simple chat website

Full article: Sialic acids, sialoconjugates and enzymes of their ...

Insights into the role of sialylation in cancer progression and ...

Webthe serum sialic acid levels in mice bearing tumors. Since these four antineoplastic drugs are all DNA chelating agents, it was proposed that the inhibition of tumor sialic acids by these drugs might be through DNA the template via two ways. Since we have found no effect of antineoplastic drugs on serum sialic acid levels in normal mice ... WebAug 22, 2016 · The “sialome” is a central axis of immune modulation that has not yet been explored in the context of cancer therapy (15–17).When sufficiently abundant, glycans terminating in sialic acid residues create a signature of healthy self that suppresses immune activation via several pathways ().Most prominently, cell-surface sialosides can recruit … rawai villas for rentWebSialic acids sweeten a tumor's life. Research output: Contribution to journal › Review › Research › peer-review. Presentation; Citation formats; Standard. Sialic acids sweeten a tumor's life. / Büll, Christian; Stoel, Marieke A; den Brok, Martijn H; Adema, Gosse J. simplechat插件

"WebThe most common sialic acids are N-acetylneuraminic acid (Neu5Ac, NeuNAc or NANA), N -glycolylneuraminic acid (Neu5Glc), and N -acetyl-9- O -acetylneuraminic acid (Neu5,9Ac 2 ). 1 Substitutions may be made at carbons C4, C7, C8, and C9 and the amine located at C5, and multiple substitutions contribute to the variety of possible structures. " - Sialic acids sweeten a tumor's life

Sialic acids sweeten a tumor's life

Sialic Acids and Sialoglycoconjugates in the Biology of Life

WebJan 8, 2024 · The book provides insights on the latest knowledge in the field of sialoglycobiology. Sialic acids as terminal residues of oligosaccharide chains play crucial roles in several cellular recognition events. Synthesized post translationally, they play an important role in recognition, signaling, immunological response and cell-cell interaction. WebJun 15, 2014 · Recent findings that emphasize the detrimental effects of hypersialylation on multiple aspects of tumor growth and behavior are reviewed and novel therapeutic …

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WebApr 1, 2024 · Section snippets Sialic Acids and Siglecs in the TME. Tumors create a local tumor microenvironment (TME) (see Glossary) consisting of different cell types, … WebNov 4, 2024 · The critical role of enzymes that regulate sialic acid in tumour cell growth and metastasis ... C., Stoel, M. A., den Brok, M. H. & Adema, G. J. Sialic acids sweeten a tumor’s life ...

WebFeb 24, 2024 · Sialic acid metabolism involves a series of enzymes responsible for the synthesis of CMP-sialic acid, which is the donor later used by different sialyltransferases … WebApr 18, 2024 · Büll C Stoel MA Den Brok MH Adema GJ ‘Sialic Acids Sweeten a Tumor’s Life’ Cancer Res 74 12 2014 3,199 3,204 10.1158/0008-5472.CAN-14-0728 24830719 Search in Google Scholar [8] Teoh, ST, Ogrodzinski, MP, Ross, C, Hunter, KW, Lunt, SY. ‘Sialic Acid Metabolism: A Key Player in Breast Cancer Metastasis Revealed by Metabolomics’, Front.

WebMay 15, 2014 · Increasing the α 2, 6 sialylation of glycoproteins may contribute to metastatic spread and therapeutic resistance in colorectal cancer. Park JJ , Lee M. Gut Liver, 7 … WebSialic acids (SA), negatively charged nine-carbon sugars, have long been implicated in cancer metastasis since 1960's but its detailed functional roles remain elusive. We present a computational analysis of transcriptomic data of cancer vs. control tissues of eight types in TCGA, aiming to elucidate the possible reason for the increased production and utilization …

WebJun 15, 2014 · Figure 1. Aberrant sialylation favors tumor growth and progression. Several factors (e.g., oncogenes, hormones, or chemotherapy) increase the expression of …

WebSialic acids are important molecule with high structural diversity. They are known to occur in higher animals such as Echinoderms, Hemichordata, Cephalochorda, and Vertebrata and … simple chat weeblyWebJan 22, 2024 · Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids … simple chatwiWebJan 22, 2024 · Sialic acids, a subset of nine carbon acidic sugars, often exist as the terminal sugars of glycans on either glycoproteins or glycolipids on the cell surface. Sialic acids … simplechat 插件WebJun 12, 2014 · Sialic Acids Sweeten a Tumor's Life Abstract. Over four decades ago, specific tumor characteristics were ascribed to the increased expression of sialic acid... rawai weatherWeb2. Functions of Sialic Acids in Tumor Biology Sialic acids on tumor cell surfaces are aberrantly expressed during tumor transformation and malignant progression. In general, … rawalakot weather reportWebSialic acid sugar-carrying glycans, sialoglycans, are aberrantly expressed on many tumor cells and have emerged as potent regulatory molecules involved in creating a tumor-supportive microenvironment. Sialoglycans can be recognized by sialic acid-binding immunoglobulin-like lectins (Siglecs), a family of immunomodulatory receptors. Most … rawak software incWebPublished OnlineFirst May 15, 2014; DOI: 10.1158/0008-5472.CAN-14-0728 Cancer Review Research Sialic Acids Sweeten a Tumor's Life €ll, Marieke A. Stoel, Martijn H. den Brok, … rawalakot weather update